Forward osmosis (FO) has played an important role in alleviating the problems caused by freshwater shortage and water contamination in recent years. However, issues of low water permeability, reverse solute diffusion, concentration polarization and membrane fouling are still widely present in FO processes. These challenges are the current research focus in exploring novel FO membranes. Fabricating FO membranes from chemically modified commercial polymers is a relatively novel approach and has proven effective in obtaining appropriate FO membranes. This paper focuses on the progress of FO membranes made specially from chemically modified polymer materials. First of all, a brief overview of commercial polymers commonly used for FO membrane fabrication is provided. Secondly, the chemical modification strategies and synthesis routes of novel polymer materials as well as the resultant FO membrane performance are presented. The strengths and weaknesses of chemical modifications on polymer materials are assessed. Then, typical FO applications facilitated by the FO membranes made from modified polymer materials are exemplified. Finally, challenges and future directions in exploring novel polymers through chemical modifications for FO membrane fabrication are highlighted. This review may provide new insights into the future advancement of both novel membrane materials and FO membranes.