Journal of the American Chemical Society, Vol.117, No.2, 653-659, 1995
Total Synthesis of Taxol .4. The Final Stages and Completion of the Synthesis
The total synthesis of (-)-Taxol has been achieved. Functional group manipulation of diol 2 provided the ABC ring system with the correct C9-keto, C10-acetyloxy functionality. Careful optimization allowed the oxidation of the C5-C6 alkene in 4 at C5 via a hydroboration reaction. Functional group manipulation of this product, 29, provided, through two routes, the oxetane D ring as 36. Following the method developed by degradative studies provided the natural enantiomer of Taxol (1).