Pleated filter cartridges with high pleat ratios and large filter surface are found to have great instances of patchy cleaning. In order to improve the intensity and uniformity of filter cleaning, a novel colliding pulse-jet cleaning method was designed and tested in this study. An experimental pulse-jet cleaning dust collector (the filtration chamber is 1225 x 750 x 1000 mm (width x depth x height)) was built with two nozzles installed over the filter cartridge (phi 320 x phi 240 x 660 mm) and on the cartridge bottom. The nozzle outlet pressure, pulse jet performance (intensity and uniformity), and compressed air consumption were studied. The effect of the trigger time difference between the top and bottom pulse jets on the performance was researched. This study demonstrated that the non-time-differenced colliding pulse-jet mode increased the pulse-jet intensity obviously to 2.56 times compared with the top-jet-only mode with some more air consumption (about 1.85 times than that in top jet-only mode), but the pulse jet uniformity slightly worsened. The pulse-jet intensity could be enhanced remarkably to 5.49 times if the colliding pulse jet was controlled in the strategy of varying trigger time difference, with the uniformity also increased obviously.