Uniform nanoparticles of Li4Ti5O12 were prepared using solid-state method coupled with Mg and Zr ions co-doped which defined as LTO-R1, LTO-R2, LTO-R3 (R = Mg/Zr). Results show that Mg-Zr doped Li4Ti5O12 have the finest particles with diameters distributed in the range of 10 to 100 nm featured relatively high specific capacity and good rate capacity. The first discharge capacity of LTO-R2 is 186.6 mAh g(-1). at 0.57C (1.0-2.6 V), and rate performance improve 56.7% at 10C compared pure LTO. The symmetrical and co-operating effect of co-doped Mg-Zr ions on the morphology and the electrochemical property of LTO were intensively discussed in this paper.