화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.73, 8-18, May, 2019
DOI10.1016/j.jiec.2019.01.021  Export Citation
Nanotherapeutics engineered to cross the blood-brain barrier for advanced drug delivery to the central nervous system
Jinhwan Kim, Song Ih Ahn, and YongTae Kim†
  • George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Parker H. Petit Institute for Bioengineering and Bioscience, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA
E-mail:
Drug delivery to the brain remains challenging mainly due to the blood-brain barrier (BBB) that regulates the entrance of substances to the brain. Advances in nanotechnology have enabled the engineering of nanomedicines for biomedical applications including enhanced drug delivery into the brain. In this review, we describe strategies of nanomedicines engineered to traverse the BBB and deliver therapeutic molecules to target brain sites. We highlight the representative applications with materials including polymers, lipids, and inorganic elements for brain drug delivery. We finalize this review with the current challenges and future perspective of nanotherapeutics for advanced drug delivery to the brain.
Keywords:Blood-brain barrier;Engineered nanoparticles;Nanomedicine;Drug delivery;Brain disease
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