NOx storage and reduction (NSR) is a cyclic catalytic process that eliminates NOx from lean burn vehicles. Leanrich switching can achieve a higher conversion than steady state operation. There is an active debate about the NOx reduction mechanism for NSR catalysts containing CeO2 (ceria), particularly at high temperatures and fast cycle frequency. In order to isolate the role of ceria, we examine the performance of a ceria-washcoated monolith for a wide range of operating conditions, including temperature, cycling frequency, reductant type and feed concentration of oxidants (O-2, CO2 and H2O). The results reveal enhancement of NO conversion with faster cycling particularly at elevated temperatures ( > 550 degrees C). The data are consistent with a cyclic mechanism in which oxygen vacancies are created during the rich feed through reduction by H-2, CO, or C(3)H(6 )and filled during the lean feed through NO and/or O-2 oxidation. An excess of O-2 is detrimental to NO conversion, due to the competing oxidation of reduced ceria by O-2. The data reveal that at least two types of vacancy sites participate in the cyclic redox process. Surface vacancy sites provide rapid NO reduction, while utilization of bulk vacancy sites is slowed by solid-state diffusion limitations. For a fixed duty cycle, lean/rich switching operation is superior to steady-state operation and an optimal lean/rich switching frequency exists for different reaction conditions. Fast cycling is especially favorable for stoichiometric feeds or cycle-averaged rich feeds.