Searching for an efficient non-platinum electrocatalyst for oxygen reduction reaction (ORR) is of great significance for some energy conversion devices. In this work, Pd-Ni-P hybrid nanocatalysts loaded on nitrogen-doped carbon supports (defined as Pd-Ni-P@NC) are prepared by simply reacting Pd(II)/Ni(II)-dimethylglyoxime with NaH2PO2 at 500 degrees C. Compared with Pd-P@NC and Ni-P@NC counterparts, the Pd-Ni-P@ NC exhibits a more positive onset potential and higher specific/mass activity towards ORR due to the interfacial coupling interaction between Pd3P0.8 and Ni2P. Moreover, it has a higher catalytic durability and better methanol tolerance than commercial Pt/C catalyst. The surface valence state analysis and electrochemistry characterization reveals that the enhanced electrocatalytic performance of Pd-Ni-P@NC is attributed to the modified Pd 3d electronic structure and improved charge transfer character, originating from the incorporation of Ni2P component. Our study provides an alternative non-platinum electrocatalyst for ORR in fuel cell and metal-air battery.