This work presents a modified solvothermal process for a facile synthesis of high thermally stable nanocrystalline anatase TiO2 NPs doped with Cu2O NPs. A Z-scheme mechanism was used to account for the enhanced photocatalytic activity exhibited by these materials. Also, the nanocomposite was impregnated in cotton fabric to obtain a modified fiber with high thermal stability, self-cleaning, enhanced UV protection, and antibacterial activity. The as-prepared nanomaterials and the coated fabric were characterized by various physicochemical techniques such as XRD, EDXRF, TGA, TEM, HRTEM, and SEM. The Cu2O/TiO2 molar ratio in the nanocomposite was found to possess a pronounced impact on the crystalline structure, size and morphology of TiO2 NPs. The XRD revealed proper substitutions of the few Ti(4+ )sites by Cu2+ ions in TiO2 host lattice. Optical measurements showed that the plasmonic peak of the Cu2O/TiO2 nanocomposite was affected by the copperdoping concentration, enhancing self-cleaning of Cu2O/TiO2 under direct sunlight. The TiO2/fiber self-cleaning efficiency (12 h for MB removal) was increased by the in situ growing of Cu2O (5.5 h). Antibacterial activity studies revealed high potential activity of Cu2O/TiO2 against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Kleissella pneumonia, Saccharomyces sp.) bacteria. The promising photocatalytic and biocidal activity of our synthesized Cu2O/TiO2 nanocomposites was ascribed to the reactive oxygen species generated by the Z-scheme mechanism under direct Sunlight.