In this work, a conceptual process design of wastewater-based algal biofuels production through hydrothermal liquefaction and hydroprocessing is proposed. Then a steady-state process simulation is performed to calculate the mass and energy analysis of the whole process for the production of hydrocarbons such as diesel, jet, gasoline, and H-2. A discounted cash flow analysis is used to calculate a minimum selling price (MSP) of the hydrocarbon fuels. The MSP of the hydrocarbon fuels is found at US$4.3/GGE. This value is comparable with the previously reported value in the literature. In addition, the sensitivity study is carried out to study the influence of both processes and economic parameters on the minimum selling price (MSP) of the hydrocarbon fuels.