The photocatalytic activity of boron-doped ZnO with varying concentration (1, 1.5 and 2% wt of B) synthesized by sol-gel method was evaluated on cyanide (CN-) degradation in aqueous solution under simulated solar radiation. The obtained catalysts were characterized by XRD, UV-vis/DRS, ICP-OES, FT-IR, and XPS. The photocatalytic experiments were carried out in a quartz batch reactor using 300 mL of cyanide solution adjusted at pH 11, evaluating different parameters such as the amount of B dopant, catalyst loading and initial concentration of cyanide solution. A 23 central composite faced design was used to maximize CN- photocatalytic degradation. The cyanide concentration was measured by ISE potentiometric method and the content of intermediate ions (OCN-, NO3-, and NH4+) was determined by UV-vis spectrophotometry. The boron incorporation into ZnO lattice (ZnO-B) reduced wurtzite crystallite size (25 nm) and narrowed the band gap (3.0 eV) compared to bare ZnO (43 nm and 3.2 eV, respectively). The ZnO-B 1.5 wt% showed better photocatalytic performance by degrading 89% of a 10 mg L-1 CN- solution compared to 75% that was reached by undoped ZnO; using in both cases 1.4 g L-1 of catalyst loading at accumulated energy of 400 kJ m(-2).