Chemistry Letters, Vol.48, No.5, 433-436, 2019
Synthesis of Transmembrane Molecules by Click Chemistry
We report here efficient synthesis of artificial transmembrane molecules (ATMs), via click chemistry of a transmembrane part and membrane-penetrating parts. Synthesized ATMs penetrated the cell membrane by Coulombic force, while they stayed on the cell membrane once they were complexed with streptavidin.