To confine the intermediate polysulfides to obstruct their dissolution from the electrolyte and increase the utilization of 4 sulfur, a novel sulfur host for decorated nitrogen-doped carbon nanotube (NCNTs) microspheres was produced by a terse (ultrasonic spraying with succedent impregnation methods. Decoration effects for Nb2O5 are better than those for Sb. Nb2O5-NCNTs microspheres are woolen-like uniform balls which are twined with CNTs and infiltrated Nb2O5 nanoparticles. Then Nb2O5-NCNTs microspheres deliver the high initial charge and discharge capacities of 1369.5 and 1335.3 mAh g(-1), good cycle stability of 1201.7 mAh g(-1) at 0.1 C after 200 cycles, and outstanding long-term cycle life of 846.2 mAh g(-1) after 1000 cycles at 2.0 C with a very low capacity decay of 0.016% per cycle. The Nb2O5-NCNTs microspheres with remarkable effects for sulfur confinement are a potential cathode material for lithium-sulfur batteries.