In this study, isothermal saturation method was used to measure and correlate the solubility of musk xylene in ten organic solvents at temperatures ranging from 278.15 K to 313.15 K, including methanol, ethanol, isopropanol, n-butanol, cyclohexane, n-hexane, n-heptane, N,N-dimethylacetamide, ethyl acetate, tetrahydrofuran. The experimental results show that the solubility of musk xylene in the selected solvent increases with increasing temperature. The experimental data were correlated by five thermodynamic models, and the results showed that each model can give a satisfactory correlation. In addition, the three kinds of mixed thermodynamic properties of Gibbs energy, enthalpy and entropy of musk xylene in selected solvents were determined by solubility data and Wilson model. It can be seen that the dissolution of musk xylene in a given solvent is spontaneous and entropy driven. Exploring the solubility of musk xylene in different organic solvents and the thermodynamics of dissolution can not only provide basic data for industrial crystallization separation, but also have great significance for its own crystallization and theoretical research. (C) 2019 Published by Elsevier Ltd.