Graphite oxide (GO) has shown immense potential in energy storage and composite filler applications, and largescale production of GO is of increasing commercial and academic interest. However, prior studies show that GO has the potential to undergo explosive decomposition. In this study, Advanced Reactive System Screening Tool was used to track the temperature and pressure of the explosive decomposition of GO. The data showed that the explosive decomposition temperature of GO strongly depends on sample size. The temperature and pressure generation are on the order of 1000s of degrees C per minute and 1000s of psig per minute respectively for less than a gram of material. Therefore, the rapid decomposition of bulk GO can lead to catastrophic consequences. The paper further compared the thermal stability of GO from different sources and found that the GO surface area has significant effects on GO stability. Finally, the Frank-Kamenetskii model was used to predict the critical mass necessary for GO to undergo explosive decomposition, the model predicted the mass within a factor of experimental data. The results of this study are beneficial in assessing and predicting the hazards of bulk GO during storage and handling.