Different amounts of Cr were added to a metastable -type Ti-22Nb (at.%) alloy to obtain desirable mechanical properties, including a low Young's modulus, high strength, and good plasticity. The mechanical properties and microstructural changes were investigated. Cr has a high ability to stabilize the phase, as well as suppress both martensite and phase transformations during quenching and the stress-induced martensite transformation during tension. Solid solution strengthening is scarcely achieved by Cr addition. The changes in mechanical properties can be attributed to the different stabilities. The Ti-22Nb-(0,1)Cr alloys have metastable phases and exhibit double yielding phenomena, indicating a stress-induced martensite transformation. The Ti-22Nb-(2,3)Cr alloys with stable phases exhibit distinct work hardening caused by a {332}<113> twinning, which also occurs in the Ti-22Nb-(0,1)Cr alloys, but not in the Ti-22Nb-4Cr alloy. Low Young's moduli of approximately 60 GPa are obtained for the Ti-22Nb-(1,2)Cr alloys. The Ti-22Nb-2Cr alloy exhibits desirable properties for biomedical applications, including an ultimate tensile strength of approximately 600MPa and elongation of approximately 20%.