This article introduces the novel concept of synthesizing waste-interception networks (WINs) and incorporates it within a mass-integration framework for the global allocation of pollutants. The essence of this notion is to provide selective interception and rerouting of undesirable species at the heart of the process instead of dealing with the pollutants in the terminal waste streams. It also provides a unified framework for simultaneously tackling gaseous and liquid pollution. Several tools are developed to track the pollutant throughout the process and determine the optimal interception policies. The problem is formulated as an optimization program that seeks to determine the optimum locations for intercepting the pollutants, extent of separation, and separating agents to carry out the interception tasks. Furthermore, the WINs can be used within a mass-integration scheme for the global allocation of species throughout the plant. These new concepts and associated mathematical formulation are demonstrated using a case study on the removal of a chlorinated hydrocarbon. This approach has benefits over conventional recycle/reuse (such as MEN synthesis).