The manuscript reports an efficient approach for the synthesis of biogenic silver (Ag) nanoparticles from Azadirachta indica leaf extract-mediated reduction of silver nitrate under solar radiation at mild temperature conditions for nanoparticles (NPs) preparation. Spectroscopic and electron microscopic characterization studies revealed the formation of stable and monodisperse Ag NPs with sharp absorption band at 438 nm and average diameter of 10-15 nm. Catalytic potential of the NPs was descriptively investigated for the reduction of 4-nitrophenol to 4-aminophenol in alkaline medium. Apparent rate constant () values were determined to be 0.014, 0.0238, 0.0338, 0.063, and 0.0794 at 5, 10, 15, 20, 40, and 50 mu L Ag NPs volume, respectively, thereby depicting linear relationship between the variables under study. Catalytic reduction of Congo red dye was achieved within 2 h, thus validating the efficacy of Ag NPs as a photocatalyst. The NPs also exhibited linear increment in antibacterial activity on cultured Escherichia coli plates with increasing volumes. These catalytic capabilities firmly advocate the applications of Ag NPs in purification of polluted water by the removal of toxic and contaminant materials and harmful/pathogenic bacteria.