The mechanical sensitivity of TKX-50 under different preparation conditions and its preparation process to explosive samples were examined. The detonation properties of TKX-50 based samples were determined. The results show that the column density can reach 1.80-1.81 g cm(-3) under the specific pressure of 3000. Different column diameters with different detonation velocities show the obvious scale effect of TKX-50 based explosives. The critical initiation pressure of TKX-50 based explosives is much higher than HMX and CL-20 based explosives, which means a much lower shock sensitivity. The determined explosion heat value of TKX-50 based explosiveis 4650 J g(-1), which is also much lower than HMX and CL-20 based explosives.