Tuning the surface property of Pt based nanocrystals at the atomic level is of vital significance to meet superior electrocatalytic performance criteria. In this work, a new strategy to advance fundamental surface study on Pt based nanocrystals is addressed by implanting foreign metals as "active auxiliaries" onto the surface of Pt based nanocrystals to engineer a stable structured catalyst. Under the guidance of this concept, the Ru component was selected as "active auxiliary" to construct Ru containing Pt3Mn catalysts by doping the isolated Ru atoms (Pt3Mn-Ru) and Ru nanoparticles (Pt3Mn@Ru) onto surface layer of Pt3Mn concave nanocubes (CNCs). Strikingly, the Pt3Mn-Ru CNCs showed the most optimal catalytic activity, durability and CO anti-poisoning ability toward ethylene glycol oxidation reaction (EGOR). The specific activity of Pt3Mn-Ru CNCs is 1.32 mA cm(-2), which is 1.47 and 3.07 times higher than Pt3Mn@Ru CNCs (0.90 mA cm(-2)) and pure Pt3Mn CNCs (0.43 mA cm(-2)). The results of in situ Fourier transform infrared spectroscopy experiments revealed that Pt3Mn-Ru CNCs were more in favor of C-C bond cleavage of EG and rapid oxidation/removal of intermediate poisonous COads. Furthermore, the theoretical calculations revealed that the Pt3Mn-Ru CNCs possessed a lower reaction barrier (1.69 eV) for oxidation of COads assisted by adsorbed OHads species, and an energy-favorable position (2.88 angstrom) for reaction between COads and OHads. This work disclosed a new tactics to develop a novel structured catalyst in possession of excellent electrocatalytic performance, which provided a promising methodology for designing Pt-based nanoparticles as efficient fuel cell catalysts.