In this study, we report the synthesis of indium tin oxide (ITO) decorated Pt-Pd nanoparticle by a simple and facile liquid phase deposition protocol and their application as a heterogeneous catalyst for the reduction of toxic hexavalent chromium. Different characterization techniques were used to confirm the synthesized nanoparticles are honeycomb-like structure. The average size of nanoparticles was found to be 2-5nm and uniformly distributed over ITO surface. During this study, the parameter was optimized such as the effect of different reducing agent and their concentration, effect of microwaves radiation and dose of nanoparticles. It was observed that the kinetic mechanism was best describes by the pseudo-first order. The synthesized Pt-Pd nanoparticles were successfully applied as an excellent heterogeneous catalyst for reduction of Cr(VI) to Cr(III) in water. The synthesized nanocatalyst was good in term of fast kinetic, high catalytic efficiency, excellent recyclability, and analytical applicability for fast and efficient reduction of toxic hexavalent chromium as compared to conventional methods of nanocatalysts. [GRAPHICS] .