The Sequential Monte Carlo/Quantum Mechanics approach was used for investigate the solvent effect on the solute-solvent structure and spectroscopic properties of Damascone derivatives, Carvone, Perillaldehyde and Menthadiene in water solution. Our in-water results have shown that the dipole moment increase of the compounds are between 36% and 84% when compared with the gas phase values and a solvatochromic shift between -20 and 14 nm whereas the magnetic properties studied have indicated an NMR shift close to 10 ppm for some carbon atoms and greater than 140 ppm for oxygen atoms.