Chemistry Letters, Vol.48, No.8, 771-774, 2019
Synthesis of Seven-membered Ring Containing Difluoromethylene Unit by Sc(OTf)(3)-catalyzed Activation of Single C-F Bond in CF3 Group
A Sc(OTf)(3)-catalyzed activation of a single C-F bond in a CF3 group is described. This reaction has two interesting features: (1) the synthesis of difluoromethylene compounds through Lewis acid-catalyzed activation of a single C-F bond in a CF3 group, and (2) the selective formation of a seven-membered ring over a five-membered ring.