This experimental study deals with cooling electronics contained in a hemispherical cavity whose cupola is maintained isothermal, being its base inclined at an angle varying from 0 degrees (horizontal disc with the cupola oriented upwards) to 135 degrees. The active component is a dome centered on this base. The space between the differentially heated elements of the assembly is filled with a porous medium of high porosity saturated by a water-copper nanofluid whose volume fraction varies between 0% (pure water) and 7%. The Rayleigh number based on the radius of the cupola reaches high values up to 7.29 x 10(10) given the important surface heat flux generated by the device during operation. The ratio between the thermal conductivity of the solid matrix and that of the base fluid ranges between 0 (interstitial volume without porous medium) and 41.4 corresponding to the intended applications. This experimental study done with an industrial prototype at scale 1 quantifies the natural convective heat transfer via the Nusselt number determined for many configurations obtained by varying the solid-fluid thermal conductivity ratio, the inclination angle, the Rayleigh number, and the volume fraction. The study clearly shows that the cooling performance of the Cu-H2O nanofluid degrades with its age and the number of times it has been used. Analysis of the results reproducibility also proves the irreversibility of the performance. The measured values were compared with those obtained in a recent numerical study based on the volume control method. The observed deviations taking into account the experimental uncertainty margins validate the mathematical model implemented in the numerical approach.