In-depth knowledge on pyrolysis behavior of lignocellulosic biomass is pivotal for efficient design, optimization, and control of thermochemical biofuel production processes. Experimental thermogravimetric analysis (TGA) is usually employed to peruse the pyrolysis kinetics of biomass samples. In addition to that, the main constituents of biomass (i.e., cellulose, hemicellulose, lignin) as well as the process heating rate can excellently reflect its pyrolysis characteristics through modeling techniques. However, the application of statistical and phenomenological models for extremely complex and highly nonlinear phenomena like lignocellulose pyrolysis is challenging. To address this challenge, adaptive network-based fuzzy inference system (ANFIS) was consolidated with particle swarm optimization (PSO) algorithm to prognosticate the kinetic constants of lignocellulose pyrolysis. More specifically, the PSO algorithm was applied to tune membership function parameters of the ANFIS model. Three ANFIS-PSO topologies were designed and trained to estimate the kinetic constants of lignocellulose pyrolysis, i.e., energy of activation, pre-exponential coefficient, and order of reaction. The input variables of the developed models were biomass main constituents and the process heating rate. The developed models could predict the kinetic constants of lignocellulosic biomass pyrolysis with an R-2 > 0.970, an MAPE < 3.270%, and an RMSE < 5.006. The pyrolysis behaviors of three different biomass feedstocks (unseen data to the developed models) were adequately prognosticated with an R-2 > 0.91 using the developed models, further confirming their fidelity. Overall, the lignocellulose pyrolysis behavior could be reliably and accurately estimated using the trained ANFIS-PSO approaches as an alternative to the TGA measurements. In order to make practical use of the trained models, a handy freely-accessible software platform was designed using the selected ANFIS-PSO models for approximating biomass pyrolysis kinetics.