The o-nitrophenylacetonitrile solubilities in some pure solvents such as n-propanol, methanol, toluene, ethanol, isopropanol, acetonitrile, acetone, cyclohexane, ethyl acetate, n-butanol, 2-butanone, isobutanol, acetic acid, water, 1,4-dioxane, and ethylbenzene were determined via a shake-flask method at temperatures from 278.15 to 333.15 K under about 101.2 kPa. Good dissolution ability was found for o-nitrophenylacetonitrile in the organic solvents. The order of solubility magnitude from high to low, except for the solvents of ethyl acetate and 1,4-dioxane, was as follows: acetone > 2-butanone > acetonitrile > toluene > (acetic acid, ethylbenzene) > methanol > ethanol > n-propanol > isopropanol > n-butanol > isobutanol > cyclohexane > water. X-ray powder diffraction analysis was carried out to analyze the solids equilibrated with the corresponding liquor, indicating that no polymorphic transformation or solvate formation took place in the 16 solvents. The correlation of the determined solubility was performed via the Wilson model, Apelblat equation, nonrandom two-liquid model, and ?h equation. Maximum root-mean-square deviation and relative average deviation were 49.66 x 10(-4) and 4.97%, respectively. The Apelblat equation presented the best correlating results among these models. In addition, the solvent-solvent and solute-solvent interactions were investigated on the basis of the approach of the linear solvation energy relationship.