Photocatalytic hydrogen (H-2) production based on semiconductors is important to utilize solar light for clean energy and environment. Herein, we report a visible light responsive heterostructure, designed and constructed by molybdenum disulfide quantum dots (MoS2-QDs) in-situ seeds-directing growth and self assemble of zinc indium sulfide (ZnIn2S4) nanosheet to ensure their full contact through a simple one-step solvothermal method for highly improved visible light H-2 production. The MoS2-QDs in-situ seeds-directing ZnIn2S4 heterostructure not only builds heterojunctions between MoS2 and ZnIn2S4 to spatially separate the photogenerated electrons and holes, but also serves as the active sites trapping photogenerated electrons to facilitate H-2 evolution. As a result, MoS2-QDs/ZnIn2S4 exhibits high photo catalytic activity for H-2 production, and the optimized 2 wt% MoS2-QDs/ZnIn2S4 (2MoS(2)-QDs/ZnIn2S4) heterostructure exhibits the highest H-2 evolution rate of 7152 mu mol.h(-1).g(-1) under visible light, similar to 9 timesof pure ZnIn2S4. Our strategy here could shed some lights on developing noble-metal free heterostructures for highly efficient photocatalytic H-2 production. (C) 2019 Elsevier Inc. All rights reserved.