(+)-Trienomycin-A, (+)-Trienomycin-B, (+)-Trienomycin-C, and (+)-Trienomycin-F and (+)-Mycotrienin-I and (+)-Mycotrienin-II - Relative and Absolute Stereochemistry

Smith AB; Wood JL; Wong W; Gould AE; Rizzo CJ; Barbosa J; Komiyama K; Omura S

Journal of the American Chemical Society, Vol.118, No.35, 8308-8315, 1996

Smith AB, Wood JL, Wong W, Gould AE, Rizzo CJ, Barbosa J, Komiyama K, Omura S

The complete relative and absolute stereochemistries have been elucidated for the ansamycin antibiotics (+)-trienomycins A, B, and C and their potent antifungal congeners, the (+)-mycotrienins I and II. A new species, (+)-trienomycin F, has also been isolated and characterized. In addition, an end-game synthetic strategy for the trienomycins and mycotrienins has been developed.

Keywords:MYCOTRIENIN ANTIBIOTICS;TRIENOMYCIN-A;ANSAMYCIN ANTIBIOTICS;STREPTOMYCES-COLLINUS;MINOR COMPONENTS;BIOSYNTHESIS;ANSATRIENIN;CONVERSION;PROTECTION;SECONDARY