Pores and framework dual responsive controlled release systems with high drug loading capacity based on HMONs (DOX@HMONs/CD) have been prepared. The DOX@HMONs/CD show high loading capacity (1060 mg/g) for anticancer drug. The cumulative release of drug diffusing from pore channels or degraded framework could be tuned by varying the pH or the concentration of dithiothreitol (DTT), and the systems exhibited an obvious enhanced release capacity in the combination of two stimulus.