It is a well known fact that morphological characteristics of aggregates influence the mechanical response of asphalt concrete (AC). Uncompacted void content (UVC) of aggregate is often related to their morphological characteristics. A detailed experimental study was performed to explore relationship between UVC and mechanical response of AC. Initially, aggregates were artificially smoothened using Los Angles abrasion testing machine. UVC was then evaluated using blended aggregates at five levels of smoothness/texture. Increasing aggregate smoothness resulted in decreased UVC values. Higher UVC was obtained with a finer gradation compared to coarse gradation. Three AC mixtures prepared using these smoothened aggregates were tested for their strength and flow properties. A linear, strong positive correlation was found between UVC and Marshall parameters (stability, Marshall quotient). This can be attributed to interparticle resistance developed during mechanical loading. Parabolic relations were found between UVC and retained Marshall parameters. The retained Marshall parameters was found to be a function of UVC. It is concluded that UVC can be effectively used to capture changes in aggregate morphology and AC response.