In this work, a novel amino-functionalized mesoporous microsphere was synthesized to remove cadmium ions from water. The Fe3O4@SiO2@m-SiO2-NH2 micro-spheres were successfully prepared via a facile two-stage process by coating of the as-synthesized magnetic cores with a silica shell followed by increasing the porosity of the structure using a cationic surfactant as structure-directing agents. The template removal from the structure has been performed following the method of solvent extraction and methanol-enhanced supercritical fluid CO2 (SCF-CO2) extraction. This novel approach provides the multifunctional microspheres with a high surface area, which improves the adsorption capacity of adsorbent. Characterization of the as-synthesized adsorbent were analytically determined showing that as-prepared adsorbent has a significant surface area of 637.38 m(2) g(-1). The kinetic data agreed with pseudo-second-order model and Langmuir isotherm. The maximum adsorption capacity of the synthesized adsorbent was about 884.9 mg g(-1), and can be easily separated from solution under an external magnetic field. The synthesized microspheres were recycled using HCl and cadmium removal was over 92% after 6 cycles, which confirms the chemical stability and reusability of the manufactured particles.