Current study describes sorption of antibiotic drug (ciprofloxacin) by using nontoxic and biocompatible carrier, i.e., wheat bran (WB). For sorption study, various parameters were optimized and Freundlich, Dubinin-Radushkevich, Langmuir, and Temkin isotherm models were applied to demonstrate the mechanism of sorption, while kinetics study for sorption was evaluated using diffusion models, pseudo-first-order kinetic (Langergren) and pseudo-second-order (Ho and McKay) kinetic models. In addition, thermodynamics study was also carried out. However, sorption of ciprofloxacin was pH depended and it showed 75% drug release in alkaline medium (at pH = 1.5) indicating the good release ability of WB for ciprofloxacin.