Fenestrations are responsible for significant amount of energy consumption in the built environment and have significant impact on daylighting and occupant visual comfort. Balance between energy consumption and occupant well-being can be achieved using automated dynamic interior shading devices. However, empirical evidence on performance of dynamic shading devices is lacking. In this study, full- scale experimental testing of two types of roller shades using two different control strategies was performed across three different orientations during varying sky conditions. Each orientation utilized one baseline room with no shading device or lighting control, and a second identical room with integrated shading and lighting control. Two different glazing types were also used to assess the performance of roller shades when used along with different glazing types. An average of 52% energy savings was obtained for lighting and 26% for cooling while maintaining acceptable levels of glare more than 90% of the time across all orientations. The impact of factors including shading device, control strategy, orientation, sky conditions and other applicable environmental variables for energy savings, visual comfort, and daylighting are also discussed. The results of this work provide full-scale testing results and informative recommendations for the utilization of dynamic roller shades in real-world scenarios.