A multilayer plasma polymer coating was deposited on small glass discs and afterwards treated with ultra violet radiation through a patterned mask to generate a micro-structured substrate with an alternating hydrophilic/ hydrophobic surface. The substrate was then immersed in a mother liqueur of the porous, functional material Metal-Organic Framework Ulm-4 (MFU-4) to preferentially grow crystals on the hydrophilic areas of the film. X-ray diffraction and electron microscope analysis showed the formation of MFU-4 single crystals.