화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.79, 41-51, November, 2019
DOI10.1016/j.jiec.2019.04.050  Export Citation
Proliferation and osteogenic differentiation of human mesenchymal stem cells in PCL/silanated silica composite scaffolds for bone tissue regeneration
Hojun Jeon, Seokhwan Yun, Eunjeong Choi1, Donggu Kang2, Keun-ho Park, Dongyun Kim, Songwan Jin, Jin-Hyung Shim, Won-Soo Yun†, and Jongbong Park†
  • Department of Mechanical Engineering, Korea Polytechnic Univesrsity, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do, 15073, South Korea
  • 1Department of Chemical Engineering & Biotechnology, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do, 15073, South Korea
  • 2Department of Mechanical System Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do, 15073, South Korea
E-mail:,
Here, we fabricated composite scaffolds consisting of poly ε-caprolactone (PCL) and silanated silica particles and evaluated the performance of these composite scaffolds as suitable alternatives for bone tissue regeneration including their physical properties (tensile modulus, wettability, and surface roughness) and biological properties (cell proliferation, osteogenic differentiation, Q-PCR, western blotting, and migration assay), by culturing human mesenchymal stem cells. PCL/silanated silica scaffolds had outstanding physical characteristics and biological properties including cell proliferation, osteogenic differentiation, and osteoinduction. This silanated-silica composite has a strong potential as a biomaterial and can be applied to bone tissue applications.
Keywords:Poly(ε-caprolactone);Silica;Silane-modification;Composite scaffolds;Human mesenchymal stem cells (hMSCs)
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