Achieving superhydrophobic surfaces is important for numerous applications ranging from self-cleaning, anti-icing, antifouling, oil-water separation to energy-efficient fluid transport. Here, we describe a facile and cost-effective strategy to fabricate superhydrophobic coatings based on lignocellulose nanofibrils (LCNF) derived from waste wheat straw, which can be applied to various substrates through a scalable coating process. Via coating with fluoroalkyl silane-modified LCNF, the superhydrophobic surfaces with water contact angle (WCA) greater than 160 degrees and sliding angle less than 10 degrees were achieved, demonstrating extraordinary water repellency. Such superhydrophobic coatings could also effectively prevent the surface from dirt contamination, positioning a self-cleaning surface capable of resisting water and dust. Additionally, the WCA of the modified LCNF coatings with a lower lignin content remained over 160 degrees even after 200 abrasion cycles, indicating the outstanding mechanical robustness. The facile fabrication technology developed would inspire novel potential applications for the sustainable biomass.