A reactive distillation and pressure-swing distillation combined process (RDPSD) for propylene glycol monomethyl ether acetate synthesis is proposed in this study. The energy requirements of RDPSD can be reduced by the introduction of heat integration. Furthermore, the vapor recompression is used in the RDPSD to enhance the energy- saving performance. Finally, the RDPSD with vapor recompression (RDPSDVR) is optimized through the heat exchanger network (HEN) for further reduction of energy consumption. The proposed processes are compared in total annual cost (TAC), total energy requirements (TER), and CO2 emissions. Based on the result of comparison of proposed processes, the RDPSDVR combined with HEN (RDPSDVR-R-L-HEN) RDPSDVR-R-L-HEN decreases by 51.83% of the TAC, 57.87% of the TER, and 62.15% that of the two-column RD, respectively. shows the best performance. The of the CO2 emissions compared with that of the two-column RD, respectively.