Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)(8)](12-) (M = Sn-IV, Pb-IV)

Yang P; Ma T; Lang ZL; Misirlic-Dencic S; Isakovic AM; Benyei A; Colovic MB; Markovic I; Krstic DZ; Poblet JM; Lin ZG; Kortz U

Inorganic Chemistry, Vol.58, No.17, 11294-11299, 2019

DOI10.1021/acs.inorgchem.9b01129 Export Citation

Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)(8)](12-) (M = Sn-IV, Pb-IV)

Yang P, Ma T, Lang ZL, Misirlic-Dencic S, Isakovic AM, Benyei A, Colovic MB, Markovic I, Krstic DZ, Poblet JM, Lin ZG, Kortz U

The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)(8)](12-) (M = Sn-IV, Pb-IV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.