An integrated model with a coupling procedure was developed to combine the dynamics of spray injections and natural draft of the dry cooling tower. By the integrated model, the interaction was clearly revealed that pre-cooling slightly reduces the buoyancy and ventilation of the tower while enhancing heat transfer, but velocity decrease of inflow air in turn promotes droplet evaporation and enhances spray cooling effects. Under an example pre-cooling system, the calculated inflow air temperature drop is about 6.6% larger than that obtained by the traditional model which neglected this interaction. Moreover, spray cooling effects on tower performance were directly quantified by the integrated model, and the tower achieved 6.94% heat dissipation improvement and 2.75% ventilation decrease. According to streamlines, effective air inflow area of the tower gradually shrinks, which promotes the formations of interferences among the injections and severely impedes the evaporation process. Especially near the inlet of the radiator, evaporation rate hardly grows, and it gets worse under the case of more nozzles. The larger droplet size and the lower droplet velocity under a smaller spray pressure are adverse to droplet evaporation, and spray cooling makes little sense at low air temperature and especially high air humidity. The proposed integrated model is a powerful tool for spray cooling research and optimization for the dry cooling tower and some other large-scale objects. (C) 2019 Elsevier Ltd. All rights reserved.