This paper presents a computational modeling of ten different configurations of microchannel heat sink (MCHS) with single phase liquid flow in order to compare their performance with the conventional MCHS. New configurations with a longitudinal and transverse arrangement of microchannels relative to the base plate, different number of coolant passages, cocurrent and countercurrent coolant supply were studied to obtain maximum thermal performance and uniform temperature distribution. The formation of the developing flow zones in a number of new configurations allowed to achieve higher Nusselt numbers and low thermal resistances at the same pumping power in comparison with conventional MCHS. The proposed methods of coolant supply make it possible to reduce the temperature gradients and improve the temperature uniformity on the base due to better distribution of coolant. (C) 2019 Elsevier Ltd. All rights reserved.