The traditional anti-aircraft and anti-missile warhead mainly hit the target by fragments or MEFPs. However, these killing elements are only effective for thin-shell ammunition (10-30 mm), but not for thick-shell ammunition (>100 mm). This paper proposes an attacking method towards thick moving target by shaped charge jet. Through the analysis of the whole penetrating process between the shaped charge jet and the thick moving target, the paper divides the process into two stages: undisturbed jet penetration and disturbed jet penetration. Based on virtual origin theory, this paper carried out detailed theoretical analysis for each stage and established theory algorithms of changes of cavity when shaped charge jet penetrates the thick moving target, penetration depth of undistributed jet, the lateral velocity of jet and penetration depth contributed by distributed jet. Since the current experimental method cannot accurately analyze the dynamic penetration process of each jet element, in order to verify the theoretical model, a diameter of 66 mm shaped charge was designed, and through the LS-DYNA software, the jet penetrates steel target with the transverse velocity of 0 similar to 600 m/s was calculated. The study also carried out detailed analysis of the jet tip and tail velocity, the shape of the penetration hole, the lateral velocity of the disturbed jet and the total depth of penetration. At the same time, we combine with the experimental data of E. Marmor et al.[22], to compare with the theoretical results. The calculations are in good agreement with the E. Marmor's experimental datas. The results indicate that shaped charge warhead is an effective method to tackle high speed thick moving target. The theoretical model established in this paper can effectively guide the structural design of the warhead.