This paper explores potential API loss mitigation during purification in recrystallization mother liquors, by including a resin adsorption step, to remove potential genotoxin impurities (PGTIs). Mometasone furoate (Meta) is used as model active pharmaceutical ingredient (API) in the presence of 4-dimethylaminopyridine (DMAP) and methyl p-toluenesulfonate (MPTS) as two model PGTIs. AG 50W-X2 and IRA68 resins efficiently removed DMAP and MPTS from methanol solutions, respectively, with adsorptions higher than 93% and Meta binding below 2%. Removal of GTIs using these resins sequentially, or combining them in a single step, was also assessed, with superior results for the later approach.