In situ catalytic fast pyrolysis of pretreated wood was investigated using a fluidized bed reactor. The pretreatments included acid leaching, torrefaction, and a combined pretreatment of acid leaching followed by torrefaction. Acid leaching reduced amounts of biomass minerals introduced into the process. However, acid leaching caused agglomeration during pyrolysis leading to reactor defluidization. Acid leaching also resulted in an upgraded bio-oil that was less deoxygenated compared to the corresponding bio-oil obtained from raw wood. Conversely, torrefaction had a beneficial effect leading to an increased yield of upgraded bio-oil without affecting its chemical composition. Torrefaction of the acid-leached wood prevented agglomeration, reversed the negative effect acid leaching had on bio-oil quality, and gave an improvement in upgraded bio-oil yield. These effects, combined with the removal of biomass minerals that are detrimental to the catalyst, suggest acid leaching coupled with torrefaction is a promising pretreatment to improve in situ catalytic fast pyrolysis of lignocellulosic biomass from a technical viewpoint.