An Al2O3-coated stainless steel wire mesh packing was prepared, aiming to serve as the monolithic catalyst support applied in a rotating packed bed (RPB) reactor. Before the application, the wetting behavior and gas-liquid mass transfer performance of Al2O3-coated wire mesh packing were investigated in this work. The results showed that the Al2O3-coated stainless steel fiber had on average 18.8% longer liquid spreading length compared with the uncoated stainless steel fiber. The gas-liquid effective interfacial area (a(e)) and the volumetric liquid-side mass transfer coefficient (k(L)a(e)) of the RPB with Al2O3-coated wire mesh packing were on average 25.9 and 45.7% higher than those with uncoated wire mesh packing, respectively. The Al2O3-coated wire mesh packing has great prospects for the catalytic reactions in the RPB reactor by providing double functions of mass transfer intensification and the monolithic catalyst support.