Transparent Nd3+,Gd3+-codoped SrF2 laser ceramic was fabricated by a single-crystal ceramization (SCC) technique, and the fluorescence properties were also characterized. The results indicated that the SCC process would lead to reducing fluorescence properties of ceramic by re-clustering small amount of Nd3+ ions. In this study, the re-clustering of Nd3+ ions were addressed by a simple thermal drive-induced grains regrowth (TDIGR) treatment. The properties of the Nd3+,Gd3+-codoped SrF2 laser ceramic undergo the TDIGR were improved and close to precursor Nd3+, Gd3+-codoped SrF2 single crystal. Meanwhile, the transmittance of ceramic (Taverage@400-1400nm 92%) was hardly affected by the TDIGR treatment. Therefore, we have reasons to believe that the combination of SCC and TDIGR is a suitable approach to obtain high optical quality neodymium, buffer ion-codoped alkaline-earth fluoride (Nd3+,B3+-codoped MF2) laser ceramics.