Ene-reductases (EREDs) catalyze the reduction of electron-deficient C=C bonds. Herein, we report the first example of ERED-catalyzed net reduction of C=C bonds of enimines (alpha,beta-unsaturated imines). Preliminary studies suggest their hydrolyzed ring-open ?omega-amino enones are the likely substrates for this step. When combined with imine reductase (IRED)-mediated C=N reduction, the result is an efficient telescoped sequence for the preparation of diastereomerically enriched 2-substituted saturated amine heterocycles.