화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.83, 173-180, March, 2020
DOI10.1016/j.jiec.2019.11.025  Export Citation
Green and direct functionalization of poly (ethylene glycol) grafted polymers onto single walled carbon nanotubes: Effective nanocarrier for doxorubicin delivery
Xuan Thang Cao1, Maheshkumar Prakash Patil2, 3, Quoc Thang Phan4, Cuong M.Q. Le4, Byung-Hyun Ahn5, Gun-Do Kim3, †, and Kwon Taek Lim4, †
  • 1Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Viet Nam, Vietnam
  • 2Research Institute for Basic Sciences, Pukyong National University, Busan, South Korea
  • 3Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan, South Korea
  • 4Department of Display Engineering, Pukyong National University, Busan, South Korea
  • 5Department of Materials Engineering, Pukyong National University, Busan, South Korea
E-mail:,
This paper reports a green and direct functionalization of poly(ethylene glycol)-graft-[furfuryl-graft-(poly (styrene-alt-maleic anhydride))] (PEG-PSMF) on the surface of single walled carbon nanotubes (SWCNTs) in aqueous media through Diels-Alder (DA) click reaction. Firstly, novel PEG grafted, furfuryl functionalized copolymers were prepared by RAFT polymerization followed by ring opening reactions. The functional copolymer was simply grafted on SWCNTs by DA reaction at room temperature under ultrasonication. The resulting hybrid materials were characterized by 1H NMR, GPC, UV.vis, FT-IR, TGA, TEM, and DLS. The hybrid materials possessed a high drug loading capacity (DLC) of doxorubicin (DOX), which could reach up to 279.9 wt.% of DLC. Moreover, in vitro drug release profiles showed that drug release rate at pH 5.5 under an acidic condition of tumor cell microenvironment was much higher than at pH 7.4 of the physiological condition. MTT assays demonstrated that the hybrid materials did not have any practical cytotoxicity against the normal HEK293 cell line, while drug loaded hybrids displayed a high antitumor activity towards HeLa cancer cells. This strategy offers a promising SWCNT-based drug carrier for tumor-targeted chemotherapy.
Keywords:Single walled carbon nanotubes;Poly(ethylene glycol);Diels-Alder click;Hybrid;Drug delivery
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