화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.28, No.3, 185-195, March, 2020
DOI10.1007/s13233-020-8087-z  Export Citation
Stimuli-Responsive Peptide Gatekeepers for Smart Nanocarriers
Jeonghun Lee, Hanwool Lee, Jiwon Kim, and Chulhee Kim†
  • Department of Polymer Science and Engineering, Inha University, Incheon 22212, Korea
E-mail:
Peptides have attracted great interests due to their potential for versatile application in preparation of drug carriers because of their specific targeting capability to desired tissues and bioresponsiveness toward various biological molecules such as enzymes for selective cleavage or bio-responsive folding into specific conformation. Therefore, the introduction of peptides as a gatekeeper on the surface would provide MSNs with triggered release property of guest molecules in response to a variety of biological stimuli including specific enzymes at specific target sites. In this review, we discuss the recent progress of peptide gatekeepers on MSNs by classification of the stimuli for triggering the release of payloads from the mesopore. We also describe the on-off gatekeepers by employing the motif of conformational transformation of peptides in response to external stimuli. The myriad biological functions of peptides by interaction with biomolecules, cells and organs endow the peptide gatekeepers on MSNs with great potential to construct smart nanocarriers.
Keywords:peptide;getekeeper;stimuli-responsiveness;mesoporous silica;smart nanocarriers
  1. Mura S, Nicolas J, Couvreur P, Nat. Mater., 12(11), 991 (2013)
  2. Coll C, Bernardos A, Martinez-Manez R, Sancenon F, Accounts Chem. Res., 46, 339 (2013)
  3. Slowing II, Vivero-Escoto JL, Wu CW, Lin VSY, Adv. Drug Deliv. Rev., 60, 1278 (2008)
  4. Vivero-Escoto JL, Slowing II, Trewyn BH, Lin VSY, Small, 6, 1952 (2010)
  5. Benezra M, Penate-Medina O, Zanzonico PB, Schaer D, Ow H, et al., J. Clin. Invest., 121, 2768 (2011)
  6. Tang FQ, Li LL, Chen D, Adv. Mater., 24(12), 1504 (2012)
  7. Huang X, Li L, Liu T, Hao N, Liu H, Chen D, Tang F, ACS Nano, 5, 5390 (2011)
  8. He Q, Shi J, J. Mater. Chem., 21, 5845 (2011)
  9. Lu J, Liong M, Li Z, Zink JI, Tamanoi F, Small, 6, 1794 (2010)
  10. Chen FH, Zhang LM, Chen QT, Zhang Y, Zhang ZJ, Chem. Commun., 46, 8633 (2010)
  11. Charnay C, Begu S, Tourne-Peteilh C, Nicole L, Lerner DA, Devoisselle JM, Eur. J. Pharm. Biopharm., 57, 533 (2004)
  12. Song SW, Hidajat K, Kawi S, Langmuir, 21(21), 9568 (2005)
  13. Zhu YF, Shi JL, Li YS, Chen HR, Shen WH, Dong XP, Microporous Mesoporous Mater., 85, 75 (2005)
  14. Park C, Lee K, Kim C, Angew. Chem.-Int. Edit., 48, 1275 (2009)
  15. Lee J, Kim H, Kim S, Lee H, Kim J, Kim N, Park HJ, Choi EK, Lee JS, Kim C, J. Mater. Chem., 22, 14061 (2012)
  16. Kim H, Kim S, Park C, Lee H, Park HJ, Kim C, Adv. Mater., 22(38), 4280 (2010)
  17. Park C, Kim H, Kim S, Kim C, J. Am. Chem. Soc., 131(46), 16614 (2009)
  18. Zhang J, Yuan ZF, Wang Y, Chen WH, Luo GF, Cheng SX, Zhuo RX, Zhang XZ, J. Am. Chem. Soc., 135(13), 5068 (2013)
  19. Radu DR, Lai CY, Jeftinija K, Rowe EW, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 126(41), 13216 (2004)
  20. Coti KK, Belowich ME, Liong M, Ambrogio MW, Lau YA, Khatib HA, Zink JI, Khashab NM, Stoddart JF, Nanoscale, 1, 16 (2009)
  21. Angelos S, Yang YW, Patel K, Stoddart JF, Zink JI, Angew. Chem.-Int. Edit., 47, 2222 (2008)
  22. Park C, Oh K, Lee SC, Kim C, Angew. Chem.-Int. Edit., 46, 1455 (2007)
  23. Patel K, Angelos S, Dichtel WR, Coskun A, Yang YW, Zink JI, Stoddart JF, J. Am. Chem. Soc., 130(8), 2382 (2008)
  24. Vivero-Escoto JL, Slowing II, Wu CW, Lin VSY, J. Am. Chem. Soc., 131(10), 3462 (2009)
  25. Lai CY, Trewyn BG, Jeftinija DM, Jeftinija K, Xu S, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 125(15), 4451 (2003)
  26. Giri S, Trewyn BG, Stellmaker MP, Lin VSY, Angew. Chem.-Int. Edit., 44, 5038 (2005)
  27. Climent E, Bernardos A, Martinez-Manez R, Maquieira A, Marcos MD, Pastor-Navarro N, Puchades R, Sancenon F, Soto J, Amoros P, J. Am. Chem. Soc., 131(39), 14075 (2009)
  28. Thornton PD, Heise A, J. Am. Chem. Soc., 132(6), 2024 (2010)
  29. Coll C, Mondragon L, Martinez-Manez R, Sancenon F, Marcos MD, Soto J, Amoros P, Perez-Paya E, Angew. Chem.-Int. Edit., 50, 2138 (2011)
  30. Lee J, Kim H, Han S, Hong E, Lee KH, Kim C, J. Am. Chem. Soc., 136(37), 12880 (2014)
  31. Torre CDI, Mondragon L, Coll C, Sancenon F, Marcos MD, Martinez-Manez R, Amoros P, Perez-Paya E, Orzaez M, Chem. Eur. J., 20, 15309 (2014)
  32. Li J, Liu F, Shao Q, Min Y, Costa M, Yeow EKL, Xing B, Adv. Healthc. Mater., 3, 1230 (2014)
  33. Zhang T, Huang S, Lin H, An N, Tong R, Chen Y, Wang Y, Qu F, New J. Chem., 41, 2468 (2017)
  34. Radhakrishnan K, Gupta S, Gnanadhas DP, Ramamurthy PC, Chakravortty D, Raichur AM, Part. Part. Syst. Char., 31, 449 (2014)
  35. Mondragon L, Mas N, Ferragud V, Torre CDI, Agostini A, Martinez-Manez R, Sancenon F, Amoros P, Perez-Paya E, Orzaez M, Chem. Eur. J., 20, 5271 (2014)
  36. Xu JH, Gao FP, Li LL, Ma HL, Fan YS, Liu W, Guo S, Zhao XZ, Wang H, Microporous Mesoporous Mater., 182, 165 (2013)
  37. Singh N, Karambelkar A, Gu L, Lin K, Miller JS, Chen CS, Sailor MJ, Bhatia SN, J. Am. Chem. Soc., 133(49), 19582 (2011)
  38. Martelli G, Zope HR, Capell MB, Kros A, Chem. Commun., 49, 9932 (2013)
  39. Torre CDI, gostini A, Mondragon L, Orzaez M, Sancenon F, Martinez-Manez R, Marcos MD, Amoros P, Perez-Paya E, Chem. Commun., 50, 3184 (2014)
  40. Li ZH, Dong K, Huang S, Ju EG, Liu Z, Yin ML, Ren JS, Qu XG, Adv. Funct. Mater., 24(23), 3612 (2014)
  41. Luo GF, Chen WH, Liu Y, hang J, Cheng SX, Zhuo RX, Zhang XZ, J. Mater. Chem. B, 1, 5723 (2013)
  42. Murai K, Higuchi M, Kinoshita T, Nagata K, Kato K, PCCP, 15, 11454 (2013)
  43. Balendiran GK. Dabur R, Fraser D, Cell Biochem. Funct., 22, 343 (2004)
  44. Estrela JM, Ortega A, Obrador E, Crit. Rev. Clin. Lab. Sci., 43, 143 (2006)
  45. Liu H, Wang H, Shenvi S, Hagen TM, Liu RM, Ann. N. Y. Acad. Sci., 1019, 346 (2004)
  46. Xiao D, Jia HZ, Zhang J, Liu CW, Zhuo RX, Zhang XZ, Small, 10, 591 (2014)
  47. Cheng YJ, Zhang AQ, Hu JJ, He F, Zeng X, Zhang XZ, ACS Appl. Mater. Interfaces, 9, 2093 (2017)
  48. Luo GF, Chen WH, Liu Y, Lei Q, Zhuo RX, Zhang XZ, Sci. Rep., 4, 6064 (2014)
  49. Cheng YJ, Qin SY, Ma YH, Chen XS, Zhang AQ, Zhang XZ, ACS Biomater. Sci. Eng., 5, 1878 (2019)
  50. Lee J, Oh ET, Yoon H, Kim H, Park HJ, Kim C, Nanoscale, 8, 8070 (2016)
  51. Verrier S, Pallu S, Bareille R, Jonczyk A, Meyer J, Dard M, Amedee J, Biomaterials, 23, 585 (2002)
  52. Majhen D, Gabrilovac J, Eloit M, Richardson J, Ambriovic-Ristov A, Biochem. Biophys. Res. Commun., 348(1), 278 (2006)
  53. Colombo G, Curnis F, De Mori GMS, Gasparri A, Longoni C, Sacchi A, Longhi R, Corti A, J. Biol. Chem., 277, 47891 (2002)
  54. Lee J, Oh ET, Song J, Kim HG, Park HJ, Kim C, Chem. Asian J., 12, 2813 (2017)
  55. Lee J, Oh ET, Han Y, Kim HG, Park HJ, Kim C, Chem. Eur. J., 23, 16966 (2017)
  56. Lee J, Oh ET, Choi MH, Kim HG, Park HJ, Kim C, New J. Chem., 42, 12938 (2018)
  57. Lee J, Oh ET, Lee J, Kang T, Kim HG, Kang H, Park HJ, Kim C, New J. Chem., 43, 1517 (2019)
  58. Lee J, Oh ET, Kang H, Kim J, Kim HG, Park HJ, Kim C, New J. Chem., 43, 11497 (2019)
  59. Lee J, Han S, Lee J, Choi M, Kim C, New J. Chem., 41, 6969 (2017)