Solvo-hydrothermal synthesis of calcium phosphate nanostructures from calcium inositol hexakisphosphate precursor in water-ethanol mixed solutions

Ji-Hoon Han; Seung Pil Pack; Sungwook Chung

Korean Journal of Chemical Engineering, Vol.37, No.5, 891-897, May, 2020

DOI10.1007/s11814-020-0496-3 Export Citation

Solvo-hydrothermal synthesis of calcium phosphate nanostructures from calcium inositol hexakisphosphate precursor in water-ethanol mixed solutions

Ji-Hoon Han, Seung Pil Pack¹, and Sungwook Chung^†

School of Chemical and Biomolecular Engineering, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241, Korea
¹Department of Biotechnology and Bioinformatics, Korea University, 2511 Sejong-ro, Sejong 30019, Korea

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We report the synthesis and characterization of crystalline calcium phosphate (CaP) nanostructures from calcium inositol hexakisphosphate (CaIP6) precursor in water-ethanol mixed solutions. We show how these CaPs can be prepared by a solvo-hydrothermal reaction and determined their compositions and structures using a battery of material characterization techniques. Our results show that only the hydroxyapatite (HAP) and dicalcium phosphate anhydrous (DCPA) phases of CaP were present in the nanostructures produced in water-ethanol mixtures, and that HAP/DCPA ratio of the rod- and plate-shaped CaP nanostructures produced were affected by the amount of ethanol present in these mixtures. The described method can be used to improve morphological control of CaP-based biomaterials and has potential use in bone regenerative medicine.

Keywords:Solvo-hydrothermal Synthesis;Calcium Phosphate;Nanostructures;Hydroxyapatite;Dicalcium Phosphate Anhydrous

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[3] Epple M, Ganesan K, Heumann R, Klesing J, Kovtun A, Neumann S, Sokolova V, J. Mater. Chem., 20, 18 (2010)

[4] Habraken W, Habibovic P, Epple M, Bohner M, Mater. Today, 19, 69 (2016)

[5] Shen YQ, Zhu YJ, Chen FF, Jiang YY, Xiong ZC, Chen F, J. Mater. Chem. B, 6, 4985 (2018)

[6] Zhao J, Liu Y, Sun WB, Zhang H, Chem. Cent. J., 5, 1 (2011)

[7] Nagano M, Nakamura T, Kokubo T, Tanahashi M, Ogawa M, Biomaterials, 17, 1771 (1996)

[8] Surmenev RA, Surmeneva MA, Ivanova AA, Acta Biomater., 10, 557 (2014)

[9] Mi R, Liu Y, Chen X, Shao Z, Nanoscale, 8, 20096 (2016)

[10] Bose S, Tarafder S, Acta Biomater., 8, 1401 (2012)

[11] Wang KW, Zhu YJ, Chen XY, Zhai WY, Wang Q, Chen F, Chang JA, Duan YR, Chem. Asian J., 5, 2477 (2010)

[12] Yang LX, Yin JJ, Wang LL, Xing GX, Yin P, Liu QW, Ceram. Int., 38, 495 (2012)

[13] Delgado-Lopez JM, Iafisco M, Rodriguez-Ruiz I, Gomez-Morales J, J. Inorg. Biochem., 127, 261 (2013)

[14] Lin KL, Wu CT, Chang J, Acta Biomater., 10, 4071 (2014)

[15] Sadat-Shojai M, Khorasani MT, Jamshidi A, J. Cryst. Growth, 361, 73 (2012)

[16] Ito H, Oaki Y, Imai H, Cryst. Growth Des., 8, 1055 (2008)

[17] Jiang YY, Zhu YJ, Chen F, Wu J, Ceram. Int., 41, 6098 (2015)

[18] Eliaz N, Metoki N, Materials, 10, 334 (2017)

[19] Haider A, Haider S, Han SS, Kang IK, RSC Adv., 7, 7442 (2017)

[20] Fihri A, Len C, Varma RS, Solhy A, Coord. Chem. Rev., 347, 48 (2017)

[21] Tas AC, J. Am. Ceram. Soc., 92(12), 2907 (2009)

[22] Cai YR, Tang RK, J. Mater. Chem., 18, 3775 (2008)

[23] Xiao DQ, Tan Z, Fu YK, Duan K, Zheng XT, Lu X, Weng J, Ceram. Int., 40, 10183 (2014)

[24] Shamsuddin A, von Fraunhofer J, US Pattern Application Publication, US 2007/0212449 A1 (2007).

[25] Grases F, Ramis M, Costa-Bauza A, Urol. Res., 28, 136 (2000)

[26] Xiao DQ, Yang F, Zhou X, Chen Z, Duan K, Weng J, Feng G, RSC Adv., 7, 44371 (2017)

[27] He ZQ, Honeycutt CW, Zhang TQ, Bertsch PM, J. Environ. Qual., 35, 1319 (2006)

[28] Goto T, Kim IY, Kikuta K, Ohtsuki C, Ceram. Int., 38, 1003 (2012)

[29] Hao LJ, Yang H, Du SL, Zhao NR, Wang YJ, Mater. Lett., 131, 252 (2014)

[30] Dardouri M, Borges JP, Omrani AD, Ceram. Int., 43, 3784 (2017)

[31] Sun RX, Yang LL, Zhang YX, Chu F, Wang GY, Lv YP, Chen KZ, CrystEngComm, 18, 8030 (2016)

[32] Ganesan K, Epple M, New J. Chem., 32, 1326 (2008)

[33] Han JH, Chung SW, Appl. Chem. Eng., 29(6), 740 (2018)

[34] Yoshimura M, Sujaridworakun P, Koh F, Fujiwara T, Pongkao D, Ahniyaz A, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 24, 521 (2004)

[35] Larsen MJ, Thorsen A, Jensen SJ, Calcified Tissue Int., 37, 189 (1985)

[36] Gelsema W, De Ligny C, Remijnse A, Blijleven H, Recueil. des. Travaux. Chimiques. Des. Pays., 85, 647 (1966).

[37] Liu XY, Bioinspiration: from nano to micro scales, Springer, New York (2012).