Interactions of dprofloxadn hydrochloride (CPFH) with sodium dodecyl sulfate (SDS) were investigated by conductivity measurement in H2O/electrolyte solutions (NaCl, Na2SO4 & Na3PO4) over 298.15-318.15 K temperature range (with 5 K interval) considering the human body temperature. In all cases, two critical micelle concentrations (c*) were observed which are increased in the presence of drug and decreased in the presence of salts enunciating the presence of interaction amongst the studied components. For (CPFH +SDS) system in the presence of salt, the c* values at 303.15 K and I = 0.50 mmol. kg(-1) followed the order: C-NaCl > C-Na2SO4 > C-Na3PO4. The G(1,m)(0) and Delta G(2,m)(0) values are found to be negative for all systems that show that the micellization process is thermodynamically spontaneous. For (CPFH + SDS) system in water, the Delta H-m(0), & Delta S-m(0) ) ,,,values reveal that the micellization processes is both entropy dominated in almost all cases. In the occurrence of electrolytes, Delta H-m(0), & Delta S-m(0) values indicate that micellization processes are both entropy & enthalpy restricted at upper temperature but it becomes totally entropy dependent at higher temperature. The higher positive Delta S-m(0) values indicate the enhanced hydrophobic interaction in presence of salts. The enthalpy-entropy compensation was determined from the linear relationship between Delta H-m(0), & Delta S-m(0) values in every state. Different transfer energies as well as compensation temperature and intrinsic enthalpy were also evaluated and the behaviors were comparable to other biological system. (C) 2019 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.