The work presents the design and analysis of a novel cryo-compressed hydrogen (CCH2) supply system. It aims to storage CCH2 (around 20 MPa and 20 K), but supply hydrogen under suitable conditions (0.16 MPa and 338 K) for fuel cell stacks. Generally, thermal waste of fuel cell occupies nearly half of the entire outcome and cannot be applied for truck driving. But in this system, original wasted energy can be reused to heat cool hydrogen, which relieves the heat burden of cooling device. This process is carefully designed and demonstrated for a 25-ton heavy duty truck. Mass flow rate in the specified CCH2 system is verified by theoretical calculating. Also, negative throttling effect of hydrogen is carefully considered for comprehensive utilization. At last, different efficiency of cryogenic heat exchangers are compared to explore the characteristics of energy consumption. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.